Malonic acid, methyl-, dimethyl ester
Propanedioic acid, 2-methyl-, dimethyl ester
Methylpropanedioic acid dimethyl ester
Propanedioic acid, methyl-, dimethyl ester
Ethylidenebis(formic acid methyl) ester
Isosuccinic acid dimethyl
Methylmalonic acid dimethyl
n20/D 1.414 (lit.)
1.098 g/mL at 25 °C(lit.)
0.2 mm Hg ( 20 °C)
First, 2,2-dimethyl-1,3-propanediol is used as a starting material, which is oxidized to a crude 2,2-dimethylmalonic acid and recrystallized to obtain 2,2-dimethylpropane Pure acid.
Then, the Lewis acid was used as a catalyst, 2,2-dimethylmalonic acid was subjected to an esterification reaction with methanol, and an alkane was used as a water carrier.
After the reaction, the solvent was distilled off and applied, and the product was washed with water, dried, and distilled under reduced pressure to obtain the product.
Dimethyl 2,2-dimethylmalonate is a versatile organic compound. Widely used in pharmaceutical piperidine acid intermediates and perfume intermediates, synthetic raw materials for pesticide intermediates.