Acetamide is also known as acetamide. The molecular formula is CH3CONH2. The chemical synthesis process of acetamide is mainly dehydration of acetic acid and ammonia. It can also be obtained by the action of acetyl chloride, acetic anhydride or ethyl acetate and ammonia.
A compound formed by the substitution of the hydroxyl group in acetic acid with an amino group.
Molecular formula CH3CONH2. Colorless crystals. Melting point 82.3 ℃, boiling point 221.2 ℃, relative density 0.9986 (85/4 ℃). Soluble in water and ethanol.
The extremely pure acetamide has no odor, and the commercial acetamide has an odor, which is due to a small amount of impurities. Has the general properties of amides.
Industrially, acetamide is prepared by heating and losing water at 150-200 ° C of ammonium acetate. It is widely used as a solvent for organic and inorganic substances. It is weakly alkaline and can be used as antacid for varnish, explosives and cosmetics. It can also be used as a wetting agent for dyeing and a plasticizer for plastics. It is also a raw material for manufacturing drugs and bactericides. N-haloacetamide produced by chlorination or bromination of acetamide is a halogenating reagent for organic synthesis.
Acetamide has many uses, and is widely used in chemical, plastic, dye, medicine, pesticide and other industries.
Acetamide derivatives N, N-dimethylacetamide (DMA) is a compound formed by the substitution of two hydrogens of an acetamide amino group with a methyl group and is often used as a solvent; N-methylacetamide is a demonstration peptide The simplest example of keys. N-Ethylacetamide is used as toughening agent, surfactant and solvent
On October 27, 2017, the preliminary list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization, acetamide was in the list of category 2B carcinogens.