Study On Liquid Phase Equilibrium Of 3-Mercaptopropionic Acid-Trichloromethane-Water Ternary System

- Oct 23, 2019-

3-Mercaptopropionic Acid CAS 107-96-0 suppliers told us that this product is an important chemical intermediate and industrial raw material. It is an important pharmaceutical intermediate for the preparation of antidepressant fenalate. It is a preparation of cross-linking agent and rust-proof. An important chemical raw material for agents, hardeners and resin additives.

At present, the main synthesis method of 3-Mercaptopropionic Acid CAS 107-96-0 is mainly a sodium hydrosulfide process, which is obtained by reacting to obtain a mixture of 3-Mercaptopropionic Acid and water, and then extracting to obtain high-purity 3-mercaptopropionic acid. .

Accordingly, as the 3-Mercaptopropionic Acid suppliers, we studied the phase equilibrium of the 3-mercaptopropionic acid-water-trichloromethane ternary system and discussed the effect of temperature and NaCl concentration on the phase equilibrium. Methyl chloride is the extractant for the extraction of high purity 3-mercaptopropionic acid to provide basic data.

3-Thiopropanoic Acid factory mentioned that Firstly, the analytical test method of China 3-Thiopropanoic Acid and chloroform was established. The determination of 3-mercaptopropionic acid by direct iodometric titration was determined, and chloroform was determined by gas chromatography. The accuracy and accuracy of the above method were confirmed by precision and recovery experiments. Then the experimental equilibrium shaking time and equilibrium standing time of the three-phase system were determined by experiments, and the raw material 3-mercaptopropionic acid was purified by vacuum distillation. The mass concentration of 3-Thiopropanoic Acid after purification was from 99.18% to 99.91% after purification, which greatly improved the accuracy of the experimental results.

3-Thiopropanoic Acid suppliers said that in their ternary liquid-liquid equilibrium data at 303.2K, 313.2K, and 323.2K were measured, and a ternary phase diagram was drawn. Then the Hand equation and Othmer-Tobias equation were used to test the liquid-liquid equilibrium data of Thiopropionic Acid-water-trichloromethane system at three different temperatures, and the reliability of the experimental results was confirmed. Then using the NRTL equation and the UNIQUAC equation to fit and predict the liquid-liquid equilibrium data at three different temperatures, the binary interaction parameters of the system are obtained.

Thiopropionic Acid suppliers said the results show that the agreement between the calculated and experimental values of the two equations is high, the root mean square deviation is less than 0.0164, and the calculated value between the predicted and experimental values is high. The root mean square deviation is less than 0.0337, indicating that the NRTL equation and the UNIQUAC equation have good applicability to the system. Finally, the effects of different NaCl concentrations on phase equilibrium were discussed. The liquid-liquid equilibrium data of NaCl mass concentration of 0%, 2% and 6% were measured by experiments. The ternary phase diagram was drawn and found along with the mass concentration of NaCl. As the rise, D and S increase, indicating that the addition of NaCl to the system facilitates the extraction of the system. The consistency of the liquid-liquid equilibrium data at different NaCl concentrations was tested using the Hand equation and the Othmer-Tobias equation, and the experimental data were fitted using the NRTL equation and the UNIQUAC equation.