Vinyl caprolactam (VC) and n-isopropyl acrylamide (MPVM), n-n-propyl acrylamide (NNPAM) copolymers have low critical solution temperature (LCST), water-soluble and non-adhesive properties , a new type of liquid embolization material for the treatment of cerebral arteriovenous malformation (AVM) endovascular embolization, can be used for further animal experiments
Poly-n-vinylcaprolactam can be used in variable temperature replacement chromatography. The so-called variable temperature replacement chromatography is to introduce a polymer into the chromatographic separation of proteins to produce a new type of temperature-dependent chromatography. Small changes in external conditions can cause only changes in the molecular structure of the polymer; from a hydrophilic, loosely coiled structure to a more hydrophobic, tightly spherical structure, or vice versa.
This property can be used to regulate the interaction between polymer molecules and chromatographic media. The poly n-vinyl caprolactam has a critical phase transition temperature of about 35 ° C, which can bind to Cibacron Blue (a dye ligand).