N-vinylcaprolactam (NVCL) is an important organic intermediate due to the presence of reactive vinyl groups in its molecule. A water-soluble temperature-sensitive polymer material can be obtained by n-vinylcaprolactam homopolymer or a grafting tool with other monomers such as glucose or dextran.
When the ambient temperature is higher than the n-vinyl caprolactam phase transition temperature, the aqueous solution exhibits thermal settling and the polymer aggregate structure changes. Temperature sensitive polymers having this property can be used to control drug release or to control chemical reactions.
Studies have shown that poly n-ethylene caprolactam (PNVCL) or copolymers with other monomers are nonionic, water soluble, heat sensitive and biocompatible, and these polymers contain hydrophilic carbonyl and amino groups, By attachment of the amino group to the hydrophobic carbon-carbon backbone, hydrolysis does not produce small molecular amino compounds that are detrimental in biomedical applications. These unique properties make it a drug carrier and have broad application prospects in the biomedical field.
The low-critical solution temperature of poly-n-vinylcaprolactam is just in the physiological temperature range (30-40 ° C), and can also be used as a new liquid embolic material for endovascular embolization of cerebral arteriovenous malformation. The use of poly-n-vinylcaprolactam in other fields has been involved in the synthesis of styling resins, UV-curing tackifiers, hair and skin care products, gas hydrate kinetics inhibitors, and the like.