Dimethyl malonate is a general organic reagent in English. Dimethyl malonate is an important raw material for the production of Pipemidic acid. Dimethyl malonate abroad is mainly used as raw material for the production of Pipemidic Acid by non-ethoxymethylene process, reacting with protoformate and urea to produce Pipemidic acid.
Chemical name: dimethyl malonate (DMM)
Chinese alias: methyl malonate; dimethyl carotene; dimethyl malonate; dimethyl malonate
English Name: Dimethyl malonate
English alias CARBOMETHOHOXYACETIC ACID METHYL ESTER; DICARBMETHOXYMETHANE; DMM; MALONIC ACID, MALONIC ACID, BIS-METHYL ESTER; MALONIC ACID DIMETHYL ESTER; METHYL MALONATETE; PROPANEDIDIOIC ACID DIMETHYL ESTER; DIMETHYL ESTER; Dimethyl ester of acid; Dimethyl ester; Dimethyl Dimethyl Dimethyl dioate; dimethylmethylmethylmethyl1,3-propanedioproppropaneaneaneanedioate; Dimalmalonate (DMM); DIDIDILONIC ACID DIDIDIDIDIDIDIDIDITETETE LOTETETE, DIDILOTETE DIDIDIDIMETMETThe results of this study are as follows:1. Hyl Malonate, > 97%; Dimethyl Malonate (Dmm) C5H8O4; Carbmethoxy acetic acid, methyl ester; prpanedioic acid dimethyl ester; DIMETHYL MALONATE 98.5%
CAS No. 108-59-8
Physicochemical properties of dimethyl malonate
Physicochemical properties of dimethyl malonate 
Molecular formula: C5H8O4
Molecular weight: 132.11
Application & Preparation:
1. Used in pharmaceuticals and organic synthesis.
2. Dimethyl malonate is an important raw material for the production of Pipemidic acid. Dimethyl malonate abroad is mainly used as raw material for the production of Pipemidic Acid by non-ethoxymethylene process, reacting with protoformate and urea to produce Pipemidic acid. At present, most of the dimethyl malonate produced by relevant enterprises in China is used to produce Pipemidic Acid except for export.
3. Comparing samples by gas chromatography and organic synthesis.
Production method: Cyanide esterification method is widely used. Sodium chloroacetate was synthesized by neutralization of chloroacetic acid and sodium carbonate, then sodium cyanoacetate was obtained by cyanidation with sodium cyanide. Sodium cyanoacetate was hydrolyzed to sodium malonate, and then esterified with methanol in the presence of sulfuric acid to obtain dimethyl malonate. The product was washed and distilled. The ester content of industrial products is more than 98%. The consumption quotas of raw materials are 1120 kg/t of chloroacetic acid, 551 kg/t of sodium cyanide and 955 kg/t of methanol. Catalytic carbonylation is the main process developed abroad. Dimethyl malonate is synthesized by one-step reaction of chloroacetate, carbon monoxide and methanol in the presence of catalyst. In contrast, the catalytic carbonylation process is advanced, but the process is complex and the reaction conditions are harsh, so it is difficult to realize industrialization.