Stone's (1943) work first proposed the existence of ethanolamine phosphate in brain tissue. He found that a small part of acid-soluble phosphorus compounds in dog brains have similar properties to this substance. Awapara, Landua & Fuerst (1950) used chromatographic methods to report the presence of this compound in the rat brain. The biochemical significance of ethanolamine phosphate in tissues is that it may act as a mediator of phospholipid metabolism. From the result
Chargaff & Keston (1940) conducted experiments with 32p ethanolamine phosphate labeled with radioactive phosphorus and concluded that the compound is not an intermediate in the synthesis of phospholipids.
It also suggests that it may be produced in the tissues due to the decomposition of phosphatidylethanolamine. In this relationship, Tyrrell (1950) recently described a type of "cerebrophospholipase" present in nerve tissue.
In this study, the presence of free ethanolamine phosphate in the rat brain has been confirmed, and the absorption of radioactive phosphorus in this compound has been measured. of
The results indicate that most of the ethanolamine phosphate present in the rat brain is not produced by the decomposition of phosphatidylethanolamine. Experiments also show that the synthesis of ethanolamine phosphate can be carried out in isolated brain tissue through a process that appears to be independent of the breakdown of phosphatidylethanolamine.