What Factors Should Be Considered When Choosing Antiepileptic Drugs?

- Mar 06, 2019-

  The choice of medication according to the type of seizure and syndrome is the basic principle of epilepsy treatment. At the same time, the following factors need to be considered: contraindications for antiepileptic drugs, possible side effects, time to reach therapeutic dose, frequency of administration and appropriate dosage form, and drug treatment for special populations: such as children, women of childbearing age, elderly, etc., drugs The interaction between the drug, the source and cost of the drug, etc., is considered by the doctor, the patient and the parent to achieve maximum efficacy and minimal side effects, and to achieve individualized medication.


  It is also meaningful to fully understand the absorption, distribution, metabolism and toxic side effects of drugs in the body. They determine the method of antiepileptic drugs, starting dose, maintenance dose, frequency of administration, course of treatment, dosage and reduction of drugs, etc. This is a factor that must be considered when selecting a drug. For example, 5,5-Dimethyloxazolidine-2,4-dione is the main raw material for the production of anti-epileptic drugs. For example, the therapeutic concentration and the poisoning concentration of phenytoin are very close. When poisoning, there may be dizziness, drowsiness, unstable walking and behavioral changes, etc. Marzipin may have a severe allergic rash, which should be considered and closely observed during treatment. Only in this way can patients be as well tolerated and compliant as possible.


  In the selection of drugs, we must pay attention to the age factor. Although children have fast metabolism and tolerance to certain drugs, some drugs such as phenytoin can affect bone development. Some drugs have obstacles to cognition and cannot be used. For the elderly, Slow metabolism, poor tolerance, combined with a variety of diseases, the opportunity to interact with a variety of drugs, easy to affect the effective therapeutic concentration of drugs; young women should also consider the drug for beauty, pregnancy, and the fetus Impact. Different ages, genders, and occupations have different requirements for life. The psychosocial needs of patients should be considered when selecting drugs.


  The extent to which epilepsy patients are accommodated by society in social life such as study, work, and entertainment is the standard for the degree of improvement of the condition. In the treatment, comprehensive analysis and individualized treatment are required.