Inexplicable Lazy, Alert To Leukopenia

- Feb 26, 2019-

  Kaley was always depressed and unhappy. When he asked, he knew that Kaley was tired after work. When he got home, he was too lazy to move. He just wanted to rest. This is not a long time. My mother-in-law has opinions, and there is a relationship between mother and daughter. Contradictions. The friend advised Kaley to go to the hospital to do a blood routine, found that white blood cells decreased, listen to the doctor explained, Kaley understood the root of his "lazy".


  White blood cells include neutrophils, lymphocytes, monocytes, eosinophils, and eosinophils. The white blood cell count of normal adults is (4.0 ~ 10.0) × 109 / L, children (5.0 ~ 12.0) × 109 / L, newborns (15.0 ~ 20.0) × 109 / L. In leukopenia, although the reduction of lymphocytes, monocytes, eosinophils, and eosinophils has an effect on the reduction in the total number of white blood cells, the reduction in the number of white blood cells is usually caused by a decrease in the number of neutrophils. The number of neutrophils in normal people is generally >1.5×109/L, (1.0~1.5)×109/L is mild neutropenia, (0.5~1.0)×109/L is moderate neutrophil Reduced, below 0.5 × 109 / L, is a severe neutropenia.

There are many causes of neutropenia, and congenital and hereditary neutropenia are rare, most of which are caused by other causes. Drugs are one of the most common causes, and possible drugs that cause neutropenia include various anticancer drugs, anti-inflammatory analgesics such as aminopyrine, paracetamol and indomethacin, anti-inflammatory drugs such as tazobactam and methylthiouracil. Antiarrhythmic drugs such as thyroid drugs, quinidine, propranolol and procainamide, antihypertensive drugs such as methyldopa and captopril, chlorpromazine, diazepam, barbiturate and Anti-epileptic drugs such as chlordiazepine sedatives, phenytoin and 5,5-Dimethyloxazolidine-2,4-dione, CAS 695-53-4. Some blood diseases, such as nutritional anemia caused by folic acid and vitamin B12 deficiency, hypersplenism, aplastic anemia, myelodysplastic syndrome, bone marrow metastasis, myelofibrosis, lymphoma, leukopenia, multiple Neutrophils can occur in myeloma and the like. Infection (viral infection, typhoid fever, paratyphoid fever, hepatitis, AIDS, etc.), immune diseases (such as systemic lupus erythematosus, etc.), occupational environmental toxicants (such as radiation, benzene, DDT, dinitrophenol, arsenic acid, strontium, one Nitrogen reduction, etc., can also cause neutropenia.

  Leukopenia often has non-specific symptoms such as fatigue, burnout, and anorexia. Because neutrophils are the "army" of the body, they are mainly responsible for resisting the infiltration of foreign pathogens. The neutrophils are reduced. Below (0.5~1.0)×109/L, infection is easy to occur, accompanied by fever and chills. Sore throat, and even cause sepsis.

  White blood cell count and classification are the most important diagnostic methods. Because white blood cell counts vary greatly due to exercise, emotional conditions, and different time points on the same day, general leukopenia often requires multiple iterations to determine. After the leukopenia is determined, the cause of leukopenia should be actively sought, but sometimes it is difficult to determine the exact cause.

  Prevention of leukopenia includes enhanced radiation protection against chronic benzene and xylene poisoning. When using drugs that cause leukopenia, white blood cells should be reviewed regularly. The treatment of leukopenia is mainly caused by etiological treatment, such as discontinuation of suspicious drugs, cessation of contact with suspected poisons, and treatment of various primary diseases that cause neutropenia. Chronic simple leukopenia, no abnormalities in bone marrow examination, stable white blood cell count and no infection, generally do not require treatment. At present, there are many varieties of leukocyte-raising drugs, and the exact curative effect is different. The first-time patients can choose one or two kinds, and each group can be replaced every 4-6 weeks until it is effective. If it does not work for several consecutive months, it is not necessary to continue. use. Commonly used drugs are shark liver alcohol, VitB4, inosine and blood. Traditional Chinese medicine includes Chinese herbal medicine extract preparations such as berbamine, ginseng tablets, etc., and Chinese patent medicines such as Buzhong Yiqi Pills and Guipi Pills.

  The doctor carefully inquired about Kaley's history of exposure to drugs and toxicants, and was diagnosed as chronic primary neutropenia after relevant examination. After a short-term application of leukocyte-producing drugs, the white blood cell count returned to normal, and he returned to work hard. Good wife, good wife.