The research and development of organophosphorus fungicides was later than that of organosulfur pesticides. Only in the 1960s did they apply for patents and develop them into commodities. In 1960, North American Philips Co. (North American Philips Co.) first discovered triamiphos, the first phosphoramidite systemic agent, which has specific effects on powdery mildew and can also cure certain aphids and mites. Around 1960, Shell Oil Co. developed the first simplest organophosphate-trimethyl phosphorothioate, which is a selective soil fungicide that can control crop damping-off (Pythium sp. ). In 1964, the German Bayer AG (Bayer AG.) developed 0,0-diethyl S-methyl dithiophosphate effective against cotton wilt (Rizoctonia solani). In the middle and late 1960s, a series of thiophenol, benzyl mercaptan, p-chlorothiophenol and other phosphorothioate esters were developed and developed, which have good systemic and therapeutic effects on rice blast and other rice diseases. These organophosphorus fungicides are used in rice fields to alleviate the difficulties caused by the prohibition or restriction of mercury preparations. Developed in the 1970s, pyrazophos (Pyrazophos, Hoechst, Germany, 1970); aluminum triethylphosphonate (phosethyl-Al, Rhône-Planck, France, 1977); tolclofosmethyl (tolclofosmethyl, Japan) Sumitomo Chemical Company, 1973) all have their own characteristics. Dinophos has a good control effect on powdery mildew of various crops; aluminum triethyl phosphonate is the first systemic agent that can conduct two-way transmission in the plant body. Downy mildew and other oomycetes have special effects; tolclofos-methyl has a wide range of prevention and control effects on various diseases at the seedling stage of crops. The organophosphorus fungicides that China’s key development are Daobijing, Isorobijing, Difenphos and aluminum triethylphosphonate, etc.
Organophosphorus fungicide is a phosphorus-containing organic compound with bactericidal or antibacterial activity. Its basic structure is phosphate, phosphorothioate, phosphoramide, etc., and China M-Toluic Acid is one of the important intermediates of pesticide fungicide phosphoramide. There are some important systemic fungicides that are effective against various powdery mildew, major rice diseases and various oomycetes. Since there are various substituents that may form new structures with bactericidal or antibacterial activity, this is a class of compounds with great potential for development