Osteoporosis

- Apr 28, 2019-

What are the clinical manifestations of osteoporosis?

(1) Pain: mainly due to accelerated bone turnover, increased bone resorption, and reduced weight-bearing strength;

(2) shortened body length, hunchback: caused by chronic compression of the vertebral body, which is one of the important clinical signs after low back pain;

(3) prone to brittle fractures: including spinal compression fractures, distal radius fractures, proximal femoral fractures.


What is the risk of osteoporosis?

Osteoporosis is a common and frequently-occurring disease. It is a serious threat to the elderly. Pain and activity are common clinical manifestations. The most serious consequence is fracture. The common sites are hip, spine, wrist and rib cage. When a spinal fracture occurs, the height can be shortened, the hunched thoracic deformity can affect the respiratory function. The fractures caused by osteoporosis in the elderly are not easy to heal, leading to prolonged bed rest, unable to take care of themselves, and mental depression, which seriously affects the physical and mental health and quality of life of the elderly. The respiratory and circulatory diseases are life-threatening and greatly increase the mortality rate of patients. 


What changes in bones in osteoporosis patients?

(1) reduction in bone mass, including a reduction in the proportion of bone minerals and bone matrix;

(2) Degeneration of the bone structure, caused by bone resorption, manifested as trabecular bone thinning, thinning, and even fracture;

(3) The strength of the bone decreases, the fragility increases, it is difficult to carry the original load, and it is easy to fracture.


Does osteoporosis require treatment?

Osteoporosis is generally a senile disease, which is mostly related to physiological decline. It is naturally irreversible like whitening of the hair and wrinkles of the skin. However, it can be delayed by medical treatment, due to the complications of osteoporosis. Severe, treatment is difficult, and the prognosis is poor. Once osteoporosis is diagnosed, anti-osteoporosis drugs should be given. Osteoporosis caused by idiopathic causes or other diseases should be directed to the cause and actively treat the primary disease.


What are the treatments for osteoporosis?

Drugs for the treatment of osteoporosis can generally be divided into the following three categories:

(1) drugs that inhibit bone resorption: including bisphosphonates, estrogen receptor modulators (SERMs), calcitonin, estrogen;

(2) promoting bone formation drugs: including fluoride preparations, parathyroid hormone (PTH), insulin-like growth factors, etc.;

(3) Other drugs: calcium preparations, vitamin D agents, strontium salts, etc.

(4) Minodronic Acid is also one of the main drugs for the treatment of osteoporosis. Our Ethyl trans-4-oxo-2-butenoate is one of the main raw materials for Minophosphoric acid.