Synthesis Of DEET N,N-diethyl-m-toluamide

- Apr 25, 2019-

Mosquitoes are one of the important vectors. They carry a variety of pathogenic microorganisms and spread various diseases such as malaria, yellow fever, dengue fever, viral encephalitis, etc., which seriously endanger human health. At present, humans generally use insecticides and repellents to control them. However, the large-scale use of pesticides is likely to cause drug resistance and environmental pollution problems, while repellents are not directly caused by mosquitoes, mainly to prevent mosquito bites. Therefore, domestic and foreign research is highly valued. The excellent repellent should have the advantages of high efficiency, long-term harm to humans and animals, low toxicity, suitable aroma and easy to carry.


It is easy to cause drug resistance and environmental pollution problems, while repellents are not directly caused by mosquitoes, mainly to prevent mosquito bites. Therefore, domestic and foreign research is highly valued. The excellent repellent should have the advantages of high efficiency, long-term harm to humans and animals, low toxicity, suitable aroma and easy to carry. The Schotten-Baumann reaction gave the target product N,N-diethylm-methylbenzamide as shown. The crude product was purified by vacuum distillation. The purified product was characterized by thin layer chromatography and mass spectrometry, and characterized by infrared spectroscopy, nuclear magnetic resonance spectroscopy and carbon spectroscopy. Finally, the mosquito repellent and mosquito repellent balm are prepared from the obtained product.


In this experiment, m-Toluic acid, 3-Methylbenzoic acid, CAS 99-04-7 was used as raw material to react with thionyl chloride to prepare m-methylbenzoyl chloride, and then Schotten-Baumann reaction was used to obtain insect repellent DEET (N,N-diethyl m-methylbenzene). The amide) had a yield of 3.1567 g and a yield of 55.0%. The crude product was purified by vacuum distillation and analyzed by thin layer chromatography and mass spectrometry. The structure was characterized by infrared spectroscopy, nuclear magnetic resonance spectroscopy and carbon spectroscopy. Finally, the mosquito repellent and mosquito repellent balm are prepared from the obtained product.