Method For Synthesizing Dimethyl 2,2-dimethylmalonate

- Mar 27, 2019-

Dimethyl 2,2-dimethylmalonate is a widely used organic compound. It is commonly used in the synthesis of pharmaceutical piperidic acid intermediates and perfume intermediates, pesticide intermediates.


The existing synthetic methods are mainly the methylation of dimethyl malonate, halogenation and acidification.


The methylation raw material used in the methylation method is dimethyl carbonate or dimethyl sulfate, catalyzed by sodium methoxide, the reaction time is long, the yield is low, the cost is high, and the dimethyl sulfate is highly toxic.


The halogenation method uses methyl iodide as a methylation reactant, and sodium methoxide catalyzes a high yield, but the cost is also high.


The acidification method is the lowest cost method. First, 2,2-dimethyl-1,3-propanediol is oxidized to 2,2-dimethylmalonic acid by using an oxidizing agent such as HN03 or KMnO4, and then 2,2-di Methylmalonic acid is esterified with methanol. The first step of the reaction process is highly polluting, with many side reactions and complicated post-processing.