Trimethadione For Epilepsy

- Mar 15, 2021-

Epilepsy (epilepsy), commonly known as "horn wind" or "sheep epilepsy", is a syndrome of abnormal high-frequency discharge of local neurons in brain tissue caused by various reasons, and spread to surrounding tissues, leading to transient brain dysfunction. In addition to genetic factors, almost all neurological diseases can induce seizures, such as infections, nerve tumors, and brain damage. The main clinical manifestations of epileptic seizures are: sudden onset, short-term motor sensory function or mental abnormalities, accompanied by abnormal EEG, often recurrent seizures.

Antiepileptic drugs can eliminate or alleviate seizures in two ways. One is to affect central neurons to prevent or reduce their pathological excessive discharge; the other is to increase the excitability threshold of normal brain tissue and reduce the spread of excitement in the lesion. Prevent the recurrence of epilepsy.

Trimethadione (Trimethoxadione, antispasmodic ketone) English name: Trimethadione (Troxidone, Tridione) Action and mechanism of action This product can increase the threshold of electrical convulsions, resist pentylenetetrazole convulsions, and have a better effect on minor epileptic seizures. Trimethyldione can reduce the excitability of the cerebral cortex and diencephalon, and shorten the subsequent discharge activity. It may act directly on the primary lesion, and has a good effect on grand epilepsy. The drug is quickly absorbed by the gastrointestinal tract and other parts, distributed in body fluids, does not bind to proteins, and is demethylated by microsomes in the liver into dimethyl ketone and corresponding dimethyl ketone metabolites. Both metabolites have anti-epileptic activity. Both trimethylketone and desmethylparamethylketone are excreted in urine, and 35%-40% are excreted daily, and almost no drug is excreted in urine.

In addition to trimethyldione, 5,5-Dimethyloxazolidine-2,4-dione is also one of the main raw materials used to treat epilepsy.